Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.

Shun He,Benjamin G Chousterman,Ashley Fenn,Atsushi Anzai,Manfred Nairz,Martin Brandt,Ingo Hilgendorf,Yuan Sun,Yu-Xiang Ye,Yoshiko Iwamoto,Benoit Tricot,Ralph Weissleder,Colin Macphee,Peter Libby,Matthias Nahrendorf,Filip K Swirski

Circulation. Heart failure（2015）

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摘要

Lp-PLA2 augments the inflammatory response after MI and antagonizes healing by disrupting the balance between inflammation and repair, providing a rationale for focused study of ventricular function and heart failure after targeting this enzyme acutely in MI.

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关键词

heart failure,inflammation,macrophages,monocytes,myocardial infarction

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