P98S100/calgranulin-mediated Inflammation Induces Fibroblast Growth Factor 23 and Promotes Cardiac Remodeling in Chronic Kidney Disease

Purpose: S100A12 and fibroblast growth factor (FGF) 23 are biomarkers for cardiovascular mortality in patients with chronic kidney disease (CKD). The present study was designed to test the hypothesis that elevated serum levels of S100/calgranulin in mice with CKD would accelerate pathological cardiac remodeling, and to discover a potential link between S100A12 and FGF23.