cAMP-signaling via EPAC1 mediates vascular endothelial cell adaptation to fluid-shear stress

Sarah Rampersad,Fabien Hubert, M Umana,Silja Freitag, Nathalie Butler,Paulina Brzezinska,Alie Wudwud,Donald H Maurice

The FASEB Journal（2015）

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摘要

Herein, we report a novel role for cAMP-signaling in human aortic endothelial cell (HAEC) adaptation to fluid-mediated shear stress (FSS). Our results showed that increases in cAMP enhanced elongat...

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