BRCA mutation carriers show normal ovarian response in in vitro fertilization cycles

Objective: To evaluate the association between carriage of BRCA1/2 mutations and ovarian performance, as demonstrated by in vitro fertilization (IVF) outcomes. Design: Retrospective cohort study. Setting: Two tertiary IVF centers. Patient(s): BRCA mutation carriers undergoing IVF for preimplantation genetic diagnosis (PGD) or fertility preservation were compared with non-BRCA PGD or fertility preservation patients, matched by age, IVF protocol, IVF center, and cancer disease status. Intervention(s): In vitro fertilization cycles for PGD and fertility preservation. Main Outcome Measure(s): Outcome of IVF: oocyte yield, poor response rate, number of zygotes, pregnancy rates. Result(s): A total of 62 BRCA mutation carriers and 62 matched noncarriers were included; 42 were fertility preservation breast cancer patients, and 82 were PGD non-cancer patients. Mean (+/- SD) age of patients was 32 +/- 3.58 years. Number of stimulation days and total stimulation dose were comparable between carriers and noncarriers. Their cycles resulted in comparable oocyte yield (13.75 vs. 14.75) and low response rates (8.06% vs. 6.45%). Number of zygotes, fertilization rates, and conception rates were also comparable. Conclusion(s): Both healthy and cancer-affected BRCA mutation carriers demonstrated normal ovarian response in IVF cycles. (C) 2015 by American Society for Reproductive Medicine.