Relationship Between Donor Oocyte Recipient Age and Embryo Implantation, Based on 998 Cycles of in Vitro Fertilization with Transfer of Fresh Embryos on Day 3 Vs Day 5

ObjectiveTo examine the relationship between donor oocyte recipient age and the outcomes of IVF cycles according to day of embryo transfer.DesignRetrospective cohort study.Materials and MethodsAll oocyte donation charts from 1/2004 to 4/2012 were reviewed; those oocyte donation recipient patients who had received a fresh embryo transfer at our institution were identified. The main outcome measures were: demographical data, peak endometrial stipe (mm), implantation rate (IR) and obstetrical outcome. Statistical analyses included ANOVA for repeated measures, two-tailed paired t-test and z-test for proportions.ResultsIn the 616 patients who had a day 3 embryo transfer, the average age was 42.39±4.07yrs with a BMI of 23.9±4.96kg/m2 and mean endometrial thickness on day of donor HCG of 10.79±5.86mm. The mean number of embryos transferred on day 3 was 2.04±0.42. For all age groups assessed between 24-51yrs, there was no significant difference with respect to IR (38%), live birth (45.94%) or miscarriage (7.63%) rates. With respect to the 382 patients who had a day 5 embryo transfer, the average age was 41.8±4.58 with a BMI of 23.27±4.56kg/m2 and mean endometrial thickness on day of donor HCG of 10.6±4.92mm. The mean number of embryos transferred was 1.89±0.37. When the recipient was <40yo, there was a significant difference in the implantation rate (52.5% vs 43.4%, p=0.001), but there was no significant difference in live birth rate (56.14% vs 50.42%) and miscarriage rate (9.5% vs 8.2%).ConclusionDespite the previous literature that suggests that there is an element of uterine aging that contributes to the age-associated decrease in fertility, this study demonstrates that oocyte donation recipient IVF outcomes are comparable across all age categories when stratified by stage of embryo development. ObjectiveTo examine the relationship between donor oocyte recipient age and the outcomes of IVF cycles according to day of embryo transfer. To examine the relationship between donor oocyte recipient age and the outcomes of IVF cycles according to day of embryo transfer. DesignRetrospective cohort study. Retrospective cohort study. Materials and MethodsAll oocyte donation charts from 1/2004 to 4/2012 were reviewed; those oocyte donation recipient patients who had received a fresh embryo transfer at our institution were identified. The main outcome measures were: demographical data, peak endometrial stipe (mm), implantation rate (IR) and obstetrical outcome. Statistical analyses included ANOVA for repeated measures, two-tailed paired t-test and z-test for proportions. All oocyte donation charts from 1/2004 to 4/2012 were reviewed; those oocyte donation recipient patients who had received a fresh embryo transfer at our institution were identified. The main outcome measures were: demographical data, peak endometrial stipe (mm), implantation rate (IR) and obstetrical outcome. Statistical analyses included ANOVA for repeated measures, two-tailed paired t-test and z-test for proportions. ResultsIn the 616 patients who had a day 3 embryo transfer, the average age was 42.39±4.07yrs with a BMI of 23.9±4.96kg/m2 and mean endometrial thickness on day of donor HCG of 10.79±5.86mm. The mean number of embryos transferred on day 3 was 2.04±0.42. For all age groups assessed between 24-51yrs, there was no significant difference with respect to IR (38%), live birth (45.94%) or miscarriage (7.63%) rates. With respect to the 382 patients who had a day 5 embryo transfer, the average age was 41.8±4.58 with a BMI of 23.27±4.56kg/m2 and mean endometrial thickness on day of donor HCG of 10.6±4.92mm. The mean number of embryos transferred was 1.89±0.37. When the recipient was <40yo, there was a significant difference in the implantation rate (52.5% vs 43.4%, p=0.001), but there was no significant difference in live birth rate (56.14% vs 50.42%) and miscarriage rate (9.5% vs 8.2%). In the 616 patients who had a day 3 embryo transfer, the average age was 42.39±4.07yrs with a BMI of 23.9±4.96kg/m2 and mean endometrial thickness on day of donor HCG of 10.79±5.86mm. The mean number of embryos transferred on day 3 was 2.04±0.42. For all age groups assessed between 24-51yrs, there was no significant difference with respect to IR (38%), live birth (45.94%) or miscarriage (7.63%) rates. With respect to the 382 patients who had a day 5 embryo transfer, the average age was 41.8±4.58 with a BMI of 23.27±4.56kg/m2 and mean endometrial thickness on day of donor HCG of 10.6±4.92mm. The mean number of embryos transferred was 1.89±0.37. When the recipient was <40yo, there was a significant difference in the implantation rate (52.5% vs 43.4%, p=0.001), but there was no significant difference in live birth rate (56.14% vs 50.42%) and miscarriage rate (9.5% vs 8.2%). ConclusionDespite the previous literature that suggests that there is an element of uterine aging that contributes to the age-associated decrease in fertility, this study demonstrates that oocyte donation recipient IVF outcomes are comparable across all age categories when stratified by stage of embryo development. Despite the previous literature that suggests that there is an element of uterine aging that contributes to the age-associated decrease in fertility, this study demonstrates that oocyte donation recipient IVF outcomes are comparable across all age categories when stratified by stage of embryo development.