The Elusive Endogenous Adipogenic Ppar Gamma Agonists: Lining Up The Suspects

The nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) is the key decisive factor controlling the development of adipocytes. Ligand-mediated activation of PPAR gamma occurs early during adipogenesis and is thought to prime adipose conversion. Although several fatty acids and their derivatives are known to bind to and activate PPAR gamma, the identity of the ligand(s) responsible for initiating adipocyte differentiation is still a matter of debate. Here we review recent data on pathways involved in ligand production as well as possible endogenous, adipogenic PPAR gamma agonists. (C) 2015 Elsevier Ltd. All rights reserved.