The Feasibility of Rabies Virus-Vectored Immunocontraception in a Mouse Model

Xianfu Wu,Todd G. Smith,Richard Franka, Min Wang,William C. Carson,Charles E. Rupprecht

Trials in vaccinology（2014）

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摘要

•We constructed a rabies virus-GnRH immunocontraceptive vaccine.•We investigated the capacity of rabies virus G in accepting GnRH copies.•The ERAg3p/2GnRH was successful in immunocontraception in a mouse model.•Our finding serves as the basis for future studies in other target animals.

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关键词

Gonadotropin-releasing hormone,Immunocontraceptive vaccine,Rabies virus,Reverse genetics,Animal population management,Non-surgical sterilization

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