8.6 Physical Separations: Behavior of Structurally Similar Molecules in the Resolution Processes

The resolution of racemic compounds with structurally similar resolving agents is examined. Summarizing experimental results, it can be established that the SDE (self-disproportionation of enantiomers) characteristic for the mixture of enantiomers of the racemic compound determines the results of the separations of the enantiomeric mixtures and the diastereomers. In addition, SDE influences the behavior of diastereomers obtained.