The Role Of Heat Shock Protein 70 In Infection And Immunity

Heat shock protein 70 (HSP70) has been the subject of intense research concerned with infectious diseases and the immune response. HSP70 is found to be associated with both host and microbial cell surface membranes where it appears to assist in the attachment and colonization of host cells by pathogens. Following infection, HSP70 readily promotes microbial survival, although in certain circumstances such as during some viral infections, it inhibits microbial growth. Regarding immunity, HSP70 induces the activation of both innate and acquired immune responses. These unique immune capabilities of HSP70 are broadly employed for the design of novel vaccines against a variety of infectious diseases.