Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

Jakob Schiøler Hansen,Jens Otto Clemmesen,Niels Henry Secher,Miriam Hoene,Andrea Drescher,Cora Weigert,Bente Klarlund Pedersen,Peter Plomgaard

Molecular Metabolism（2015）

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摘要

•In humans, the splanchnic bed contributes to the systemic FGF-21 levels during rest and exercise.•Under normo-physiological conditions FGF-21 is not released from the leg in humans.•In humans, a dynamic interaction of glucagon-to-insulin ratio regulates FGF-21 secretion.

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关键词

Liver,Hepatic,Hepatokine,Exercise

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