C-C Cross-Coupling: New Methodologies, Applications And Discoveries Over The Last Few Years

The possibility of obtaining new C-C bonds from the transition metals mediated catalysis, has represented a major advance in Organic Synthesis and correlated areas such as Chemistry of Natural Products and Medicinal Chemistry, since synthetically unreachable molecules could be obtained in an efficient and chemosselective way, from simple reactants. The cross-coupling reactions, as some of these processes are called, have gained prominence since the original publications of Suzuki-Miyaura, Kumada-Tamao-Corriu, Mizoroki-Heck, Sonogashira, Stille - during the 1970's - and Hiyama - in 1988. Since then numerous efforts are made by scientists around the world in order to not only understand better these processes, but also develop new catalytic systems with more efficiency and applicable to a wider range of substrates and the concepts of Green Chemistry. This work aims to expose some of the advances published by scientists around the world, in the last six years, based on this theme.