Beauty and the beat: A complicated case of multifocal ectopic Purkinje-related premature contractions.

Key Teaching Points•Frequent multifocal fascicular-Purkinje-related premature ventricular complexes with or without dilated cardiomyopathy should raise the suspicion of SCN5A channelopathy. This can imply an increased risk of sudden cardiac arrest.•Amiodarone-associated excessive QT prolongation and torsades de pointes should prompt genotyping of the patient.•Combined clinical, genetic, and cellular analyses enable individualized patient care and facilitate personalized arrhythmia therapy. •Frequent multifocal fascicular-Purkinje-related premature ventricular complexes with or without dilated cardiomyopathy should raise the suspicion of SCN5A channelopathy. This can imply an increased risk of sudden cardiac arrest.•Amiodarone-associated excessive QT prolongation and torsades de pointes should prompt genotyping of the patient.•Combined clinical, genetic, and cellular analyses enable individualized patient care and facilitate personalized arrhythmia therapy.