Radiolabeled Antiplatelet Monoclonal Antibodies for the Scintigraphic Localization of In-vivo Thrombi and Vascular Lesions

Detection of thrombi in the extremities and in the trunk, including coronary and carotid thrombi, is extremely important. of equal importance is the ability to visualize the interaction between blood platelets and the arterial wall in thrombosis and intimai damage where platelet deposition occurs. In-vivo imaging would allow: (i) thrombus detection before thrombolytic therapy is instituted, and the monitoring of thrombosis once therapy is discontinued; (ii) monitoring platelet deposition on vessel walls following balloon angioplasty; and (iii) monitoring for acute occlusion of coronary artery bypass grafts. Quantitative imaging could permit visualization of coronary and carotid artery occlusion and thrombogenic and thrombolytic activity within the arterial circulation to the heart, lung, and the brain with better effectiveness.