Four Common Genetic Variants Increase Susceptibility To Prostate Cancer In The Spanish Population

22045 Background: Prostate cancer is the neoplasm with highest incidence in Spanish males. Epidemiology shows that familial antecedents are a significant risk factor. We aim to look for genetic variants associated to susceptibility to prostate cancer in the Spanish population. Methods: Within a multinational genome-wide association study coordinated by Decode Genetics in 3490 consenting patients diagnosed with prostate cancer and 14345 controls, Spain contributed with 456 patients y 1078 controls. >300.000 polymorphisms have been assessed with the Infinium II method (Illumina platform). Results: Four common genetic variants associated to prostate cancer have been identified. Two of them (rs 1447295 and rs 16901979A) are located in 8q24. Frequencies of these in Spain (cases/controls/relative risk/2-tailed p) are 10.3%/7.4%/1.71/0.005 y 6.6%/4.0%/1.44/0.017. In Europe, relative risks/2-tailed p are 1.79/1.1 × 10−12 y 1.60/6.4 × 10−8 respectively. Populational attributtable risk is 12%. Two other variants are located in 17q (rs4430796 and rs1859962). Frequencies of these in Spain (cases/controls/relative risk/2-tailed p) are 46.9%/45.4%/1.06/0.45 y 51.2%/47.6%/1.15/0.071. Worldwide, relative risks/2-tailed p are 1.24/2.02 × 10−7 and 1.20/2.5 × 10−10 respectively. Populational attributtable risk is 36%. The first of these two variants had been previously reported as protective for type 2 diabetes mellitus.The implications of these findings will be presented. Conclusions: Four frequent genetic variants are associated to susceptibility to prostate cancer in the Spanish population. They are involved in 47% of all cases of this neoplasm in Spain. No significant financial relationships to disclose.