Effect of Soyasaponin on Pulmonary Tissue Apoptosis of Silicotic Fibrosis Rats

Objectives To discuss effect of SS on pulmonary tissue apoptosis of Silicotic Fibrosis Rats. Methods It was observed concluding nitrous oxide (NO) and reactive oxygen species (ROS) in serum and changes of that after SS intervened. Analysis of apoptosis of pulmonary tissue cells: Apoptosis was detected by TdT-mediated dUTP nick end labeling (TUNEL) to determine the changes of morphology and apoptotic index. Results After SS intervened, the level of ROS, NO were all decreased significantly (P < 0.05). TUNEL showed that apoptotic index descented remarkably. But we could also observe the appearance of apoptosis in alveolar epithelial cells and pulmonary vascular endothelial cells. Conclusion A certain dose of SS might relieve the progress of silicotic pulmonary fibrosis through reducing excessive apoptosis of pulmonary tissue.