Polimorfismo A986S del receptor sensor del calcio y fracturas clínicas osteoporóticas

Summary Introduction: The relationship between osteoporosis and arterial hypertension has not been clearly esta- blished, with alterations in calcium metabolism having been reported in the latter which may explain their association. Our objective was to establish the relationship between the A986S polymorphism of the cal- cium-sensing receptor (CaSR) and the presence of osteoporotic clinical fractures in a group of patients with hypertension. Material: Prospective observational cohort study in 71 patients with hypertension, from 2001 to June 2014. We obtained socio-demographic and clinical data, including osteoporotic clinical fractures. The CaSR polymorphism was analysed using molecular techniques. The data was analysed using SPSS 15.0 (p<0.5) Results: 43.77% of the patients were men and 56.3% women. Genotype AA was found in 67.6% of patients, genotype SS in 2.8% and genotype AS in 29.6%. Those with genotype AA did not have higher comorbidity (27% vs 26%, p=0.9) or more pathological fractures (14.6% vs 21.7%, p=0.4) than the others. In the subgroup of women, 11 osteoporotic clinical fractures were recorded, without there being any dif- ferences between those with the AA genotype and the others (28% vs 27%, p=0.9). Conclusions: We found no association between the A986S polymorphism and the presence of osteopo- rotic clinical fractures in our cohort.