Performance of a Multispectral Optoacoustic Tomography (MSOT) System equipped with 2D vs. 3D Handheld Probes for Potential Clinical Translation

•Both the 2D and 3D handheld MSOT systems hold promise for clinical translation.•The 2D MSOT handheld probe provides high resolution, sensitivity, accuracy and reliability.•The 3D MSOT handheld probe adds unique 3D capabilities and shortens imaging time.