Gene Expression: Basic Concepts

Abstract Originally published in: Analysing Gene Expression. Edited by Stefan Lorkowski, Paul Cullen, Copyright © 2003 Wiley‐VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3‐527‐30448‐2 The sections in this article are Introduction Basics of Transcription and Translation in the cell Introduction Transcription Translation Summary Regulation of transcription Introduction m RNA expression profiles – the transcriptome Protein expression profiles — the proteome Interaction between genes and proteins – the interactome The transcription machinery and core promoters Regulatory promoters Enhancers Locus control regions Matrix attachment regions Insulators RIDGEs – Regions of increased gene expression Enhanceosomes Chromatin Silencer elements Transcription factors, repressors and co‐repressors Epigenetics Conclusions