Mutated Jak Kinases And Deregulated Stat Activity Are Potential Therapeutic Targets In Cutaneous T-Cell Lymphoma

Cristina Perez,Julia Gonzalez-Rincon, Arantza Onaindia,Carmen Almaraz,Nuria Garcia-Diaz,Helena Pisonero,Soraya Curiel-Olmo, Sagrario Gomez,Laura Cereceda, Rebeca Madureira, Mercedes Hospital,Dolores Suarez-Massa, Jose L. Rodriguez-Peralto,Concepcion Postigo,Alicia Leon-Castillo, Carmen Gonzalez-Vela,Nerea Martinez, Pablo Ortiz-Romero,Margarita Sanchez-Beato, Miguel A. Piris,Jose P. Vaque

HAEMATOLOGICA（2015）

引用 67|浏览50

暂无评分

摘要

The malignant mechanisms that control the development of cutaneous T-cell lymphoma (CTCL) are starting to be identified. Recent evidence suggests that disturbances in specific intracellular signaling pathways, such as RAS-MAPK, TCR-PLCG1-NFAT and JAK-STAT, can play an essential role in the

查看译文

关键词

JAK mutations,CTCL,ruxolitinib,JAK/STAT,targeted therapy,molecular diagnostics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要