Variant IRAK-1 haplotype is associated with increased NF-?B activation and worse outcomes in sepsis

Abstract Rationale: The interleukin-1 receptor-associated kinase (IRAK-1) plays a central role in TLR2 and TLR4 induced activation of NF-κB, a critical event in the transcriptional regulation of many sepsisassociated,proinflammatory mediators. There are two haplotypes for the IRAK-1 gene in Caucasians, with the variant haplotype consisting of 5 intron single nucleotide polymorphisms,(SNPs) and 3