Evaluation Of Alk-1 Expression In Circulating Endothelial Cells (Cecs) As An Exploratory Biomarker For Pf-03446962 Undergoing Phase I Trial In Cancer Patients

Patrizia Mancuso,David R Shalinsky,Angelica Calleri,Jessica Quarna,Pierluigi Antoniotti, Iman Jilani,Dana D Hulowe,Xin Jiang, C Gallostampino,Francesco Bertolini

JOURNAL OF CLINICAL ONCOLOGY（2009）

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摘要

3573 Background: ALK-1 is a member of the TβRI family \u0026 a novel target for antiangiogenic therapy (Rx). PF- 03446962 (PF) is a fully human mAB (IgG2, κ) generated against ALK-1 with dose-dependent ...

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