Translocation between Chromosomes 11 and 22[t(11,22)]: the Most Common Non RobertsonianTranslocation; Evaluation of 38 Cases of t(11,22)and a Review of the Literature

Chromosomal aberrations are one of the major reasons of congenital diseases. The most common chromosomal abnormality is translocation, especially Robertsonian translocation. Among 88900 karyotypes that were analyzed in our center, there were 1542 cases translocation of which 387 (25%) were Robertsonian. There were also 38 (3.3%) cases of t(11,22), which was the most common translocation in 1165 cases of non Robertsonian translocation. The high prevalence of abortion in the carriers of balanced translocation and the adverse manifestations of non balanced t(11,22) demand attention, especially in women with recurrent miscarriage. Translocation between Chromosomes 11 and 22 [t(11,22)]: the Most Common Non Robertsonian Translocation; Evaluation of 38 Cases of t(11,22) and a Review of the Literature Mohammad Hassan Kariminejad, Azadeh Moshtagh, Roxana Kariminejad ABSTRACT * Mohammad Hassan Kariminejad, MD Prof. of Pathology, Tehran University of Medical Scienes Chairman of Iranian Neurogenetics Society Kariminejad-Najmabadi Pathology and Genetics Center Email: mhkariminejad@yahoo.com Submission Date: 27/ July/ 2013 Acceptance Date: 1/ Sep/2013 * Key words: Translocation, Genetic; Chromosomal Aberrations; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Karyotype.