Altered brain functional connectivity in patients with benign childhood epilepsy

Event Abstract Back to Event Altered brain functional connectivity in patients with benign childhood epilepsy Azeez A. Adebimpe1*, Ardalan Aarabi1, Mahdi Mahmoudzadeh2, Emilie Bourel-Ponchel2 and Fabrice Wallois1, 2 1 Université de Picardie Jules Verne, GRAMFC Laboratory, INSERM U1105, Faculty of Medicine, France 2 University Hospital of Amiens, CHU NORD, GRAMFC Laboratory, INSERM U1105 , France Alteration of functional connectivity may be a key feature for better understanding the pathology of epilepsy. In this study, we investigated how the dynamics of the healthy brain differ from the state of the brain of patients with benign childhood epilepsy during the resting state. To address this issue, we used resting state EEG to characterize functional brain connectivity in controls and epileptic patients. Using imaginary coherence and graph metrics, we found significant differences in functional connectivity between the control and epileptic groups within the theta (4-8 Hz) and alpha (9-13 Hz) bands. In particular, significant differences in functional connectivity and clustering coefficients were observed between epileptic patients and controls within different frequency bands. In the presence of interictal epileptiform discharges (IEDs), epileptic patients demonstrated significant increases in alpha coherence in the epileptogenic zone. However, patients showed lower alpha coherence in the frontal region in comparison with controls when EEG contained no IEDs. Similarly, the clustering coefficient decreased significantly in alpha band for epileptic patients in the absence of IED in comparison with normal subjects. These findings show altered resting state brain dynamics and functional connectivity in patients with benign childhood epilepsy in a frequency dependent manner. Figure 1 References [1] C.P. Panayiotopoulos, Benign childhood partial seizures and related epileptic syndromes. London: John Libbey & Company Ltd, 1999. [2] P. Loiseau and M. Beaussart, “The seizures of benign childhood epilepsy with Rolandic paroxysmal discharges,” Epilepsia, vol. 14, pp. 381–389, Dec. 1973. [3] G. Nolte, O. Bai, L. Wheaton, Z. Maron, S. Vorbach and M. Hallet, “Identifying true brain interaction from EEG data using the imaginary part of coherency,” Clin. Neurophysiol., vol. 115, pp. 2292-22307, Oct. 2004. [4] G. Deco and M. Corbetta, “The dynamical balance of the brain at rest”, Neuroscientist, vol. 17, pp. 107-123, Dec. 2010. Keywords: EEG, benign childhood epilepsy., functional connectivity, coherence, benign childhood epilepsy, resting state Conference: Neuroinformatics 2014, Leiden, Netherlands, 25 Aug - 27 Aug, 2014. Presentation Type: Poster, to be considered for oral presentation Topic: Neuroimaging Citation: Adebimpe AA, Aarabi A, Mahmoudzadeh M, Bourel-Ponchel E and Wallois F (2014). Altered brain functional connectivity in patients with benign childhood epilepsy. Front. Neuroinform. Conference Abstract: Neuroinformatics 2014. doi: 10.3389/conf.fninf.2014.18.00063 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Apr 2014; Published Online: 04 Jun 2014. * Correspondence: Mr. Azeez A Adebimpe, Université de Picardie Jules Verne, GRAMFC Laboratory, INSERM U1105, Faculty of Medicine, Amiens, 80000, France, azeez.adebimpe@outlook.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Azeez A Adebimpe Ardalan Aarabi Mahdi Mahmoudzadeh Emilie Bourel-Ponchel Fabrice Wallois Google Azeez A Adebimpe Ardalan Aarabi Mahdi Mahmoudzadeh Emilie Bourel-Ponchel Fabrice Wallois Google Scholar Azeez A Adebimpe Ardalan Aarabi Mahdi Mahmoudzadeh Emilie Bourel-Ponchel Fabrice Wallois PubMed Azeez A Adebimpe Ardalan Aarabi Mahdi Mahmoudzadeh Emilie Bourel-Ponchel Fabrice Wallois Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.