Immunotherapy with VGX-3100 (HPV16 and HPV18 Plasmids) + INO-9012 (DNA Encoding IL-12) in Human Papillomavirus (HPV) Associated Head and Neck Squamous Cell Carcinoma (hnscca): Interim Safety and Immunogenicity Results

Charu Aggarwal,Roger Cohen,Matthew P Morrow,Joshua Bauml,Gregory Weinstein,Jean Boyer,Xuefei Shen,Jian Yan, Jessica Goldenberg, Drishty Nashit,Sandra Oyola,Jessica Lee,Laurent M Humeau,David B Weiner, Zane Yang,Mark L Bagarazzi,David Weiner

Journal for immunotherapy of cancer（2015）

引用 11|浏览18

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摘要

Meeting abstracts Oropharyngeal HNSCCa is frequently associated with HPV infection. DNA-based Immunotherapy with plasmids encoding HPV16 and HPV18 E6/E7 antigens has been shown to generate robust immune responses in women with HPV-driven high-grade cervical dysplasia. We hypothesize that HPV-

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关键词

Cervical Dysplasia,Injection Site Pain,Robust Immune Response,Adequate Organ Function,Exploratory Endpoint

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