On-line Anti-Acetylcholine Esterase Activity of Extracts of Oxystelma esculentum, Aerva javanica and Zanthoxylum armatum

Alzheimer's disease (AD), a disease of brain, resulting in memory impairment and the loss of thinking. The main reason of Alzheimer's disease is firmly associated with some impairment in cholinergic transmission. This impairment may be improved by diminishing the breakdown of acetylcholine at the synaptic site in the brain by inhibiting acetylcholinesterase (AChE). In this work, extracts of three different plants Oxystelma esculentum (OEM), Aerva javanica (AJM) and Zanthoxylum armatum (ZAA) have been screened for their anti-AchE activity. Results of the study demonstrate that of the studied extracts, ZAA [IC50 55.5 mu g/ml] acquired stronger anti-AChE activity. While OEM with IC50 107.2 mu g/ml showed moderate and ZAE and AJM showed weaker action [IC50 182.5 and 275.2 mu g/ml]. Galanthamine was used as a positive control [IC50 1.47 mu g/ml].