P021 Glucagon-like peptide-2 modulates the production of proinflammatory cytokine interferon-γ in human blood and intestinal dendritic cells a potential new therapy for Crohn's disease

differences between the three groups. A similar result was observed on myofibroblasts from the same patients. IL-17A but not IL-17E significantly increased collagen production and TIMP-1 expression, mainly in the supernatants of CD strictured myofibroblasts. Migration of CD strictured, CD non-strictured and control myofibroblasts was significantly inhibited by IL-17A but not IL-17E, with no significant differences between the three cell populations. Conclusions: Our results suggest that IL-17A but not IL-17E is profibrotic in CD. Further studies are needed to clarify the signaling pathways mediating the differential effects of these two cytokines in the gut of CD patients.