The development of a high-performance liquid chromatography–tandem mass spectrometric method for simultaneous quantification of morphine, morphine-3-β-glucuronide, morphine-6-β-glucuronide, hydromorphone, and normorphine in serum
Clinical Biochemistry（2015）
Abstract
•HPLC/MS/MS method validation for morphine and its metabolites•Method validation followed the new CLSI C62-A guidelines.•Analytical measuring range for all analytes was determined to be 5 to 1000ng/mL.•Method required small sample volume (50μL) of serum or plasma.
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Key words
HPLC–MS/MS,Neonatal abstinence syndrome,Morphine,Glucuronide,Method validation
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