Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides
Molecular Immunology(2015)
Abstract
•The endogenous ligands of NKT cells are α-linked monoglycosylceramides.•α-Linked monoglycosylceramides were thought to be absent from mammalian lipidomes.•New tools have been built to study the chemical structure of glycolipids.•Availability of endogenous α-galactosylceramide is regulated by degradation.
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Key words
NKT cells,Endogenous ligand,Ceramide,Anomers,Contamination,Thymic selection
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