Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells

Margaret A Lindorfer,Erika M Cook,Jillian C Tupitza,Clive S Zent,Richard Burack,Rob N De Jong,Frank J Beurskens,Janine Schuurman,Paul W H I Parren,Ronald P Taylor

Molecular Immunology（2016）

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摘要

•mAbs that form hexamers on binding to nucleated cells promoted killing in <2min.•Influx of Ca2+ appears to be the most proximate mediator of CDC-promoted cell death.•CDC steps were visualized by multispectral image analyses and in four-color movies.

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关键词

Al,CLL,CDC,GMI,HI,Hx,MAC,MESF,NHS,OFA,RTX,TMRM,WT

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