Altered neural signaling and immune pathways in peripheral blood mononuclear cells of schizophrenia patients with cognitive impairment: a transcriptome analysis.
Brain, Behavior, and Immunity（2016）
Abstract
•WNT pathway was down-regulated in CD and SZ groups, but not in the CS group.•Suppression of WNT signaling was a defining feature of cognitive decline in SZ.•CS, CD and SZ were characterized by the up-regulated pathways in immune dysfunction.•CS, CD and SZ were characterized by the up-regulated pathways in energy metabolism.
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Key words
Schizophrenia,Gene expression,Cognition,Immune,Development
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