Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia

Meray Serdar,Josephine Herz, Karina Kempe,Katharina Lumpe,Barbara S. Reinboth,Stéphane V. Sizonenko,Xinlin Hou,Ralf Herrmann,Martin Hadamitzky,Rolf Heumann,Wiebke Hansen,Marco Sifringer,Yohan van de Looij,Ursula Felderhoff-Müser,Ivo Bendix

Brain, Behavior, and Immunity（2016）

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摘要

•Fingolimod (FTY720) improves long-term cognitive deficits after neonatal hyperoxia.•Hyperoxia-related long-term microstructural abnormalities are diminished by FTY720.•FTY720 attenuates hyperoxia-induced hypomyelination.•Oligodendrocyte degeneration and impaired maturation are ameliorated by FTY720.•FTY720 reduces cerebral hyperoxia-induced oxidative stress and inflammation.

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关键词

Neonatal brain injury,Hyperoxia,Oligodendrocyte,White matter development,Fingolimod

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