ChemInform Abstract: Isoquinoline Derivatives as Potent CRTH2 Receptor Antagonists: Synthesis and SAR.

Rie Nishikawashimono,Yoshinori Sekiguchi,Takeshi Koami,Madoka Kawamura,Daisuke Wakasugi,Kazuhito Watanabe,Shunichi Wakahara,Kayo Matsumoto,Tetsuo Takayama

Cheminform（2012）

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摘要

The most potent compound, TASP0376377 (I) shows good CRTH2 antagonist potency, as well as sufficient selectivity for binding to CRTH2 over the DP1 prostanoid receptor and COX-1 and COX-2 enzymes.

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structure activity relationship

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