ChemInform Abstract: Improved Protocols for the Selective Deprotection of Trialkylsilyl Ethers Using Fluorosilicic Acid.

Improvements for the application of aqueous fluorosilicic acid to the selective cleavage of tert-butyldimethylsilyl ethers in the presence of triisopropylsilyl ethers are described. Deprotection conditions have been optimized for cleavage selectivity, tolerance by acid-labile compounds, and cleavage rate. Mechanistic features of the desilylation reaction are discussed