Epidemiological burden of invasive pneumococcal disease in children and adolescents with predisposing risk factors

•Total population at risk ranged from 17.3 to 64.6 million.•According to SIREVA 2012, PCV13 offered a 62.9% coverage in Latin America.•Potentially covered population was 10,906,356-40,622,078 with PCV13.•Hypothetical immunized population ranged from 11.4 to 42.4 million, approximately.•Vaccinating against IPD in high-risk individuals is a major opportunity.