Administration of somatostatin analog octreotide in the ventrolateral orbital cortex produces sex-related antinociceptive effects on acute and formalin-induced nociceptive behavior in rats

•Octreotide into the VLO depressed the tail flick reflex only in female rats.•Cyclo-somatostatin antagonized octreotide-induced antinociception of tail flick reflex in female rats.•Octreotide into the VLO depressed formalin-induced flinching response only in female rats, but not male rats.•Cyclo-somatostatin antagonized octreotide-induced antinociception of formalin-induced flinching response in female rats.