Central Obesity is Associated with Non-Cirrhotic Portal Vein Thrombosis.

Background & Aims: 30-40% of portal vein thrombosis (PVT) remains of unknown origin. An association between metabolic syndrome (MetS) and peripheral vein thrombosis has been reported but not with PVT, to date. The aim of this study was to investigate the association between MetS and PVT.Methods: Between 2003 and 2014, all consecutive patients with non-cirrhotic PVT were prospectively included. Patient's characteristics and risks factors were recorded at the time of inclusion. Controls were selected by random in the general population and were matched 1/1 according to age and sex.Results: Seventy-nine patients with PVT were included: 40 present with at least one risk factor for PVT (SPVT) and 39 were found to be idiopathic (IPVT). The prevalence of MetS was 25.6% in SPVT group vs. 47.4% in IPVT group and 17.9% in controls from the general population (C-IPVT: p = 0.01). The waist circumference and body mass index were higher in the IPVT group than in the SPVT group (105 vs. 93 cm, p = 0.004 and 29.4 vs. 25.0 kg/m(2), p = 0.004) and in the C-IPVT group (105 vs. 92 cm, p = 0.001 and 29.4 vs. 25.8 kg/m(2), p = 0.003). Overweight was observed in 82.0% of patients in the IPVT group vs. 44% in the SPVT group (p = 0.002) and 51% in the C-IPVT group (p = 0.01). The mean visceral fat area was higher in IPVT than in SPVT (18,223 mm(2) vs. 12,690 mm2, p = 0.02). In multivariate analyses, an increase in waist circumference was the strongest parameter associated with idiopathic PVT.Conclusion: Central obesity is associated with PVT and could become one of the main risk factors for digestive thromboses. (C) 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.