Synthesis of 2‐Amino‐3‐cyano‐4H‐chromene‐4‐carboxamide Derivatives by an Isocyanide‐Based Domino Conjugate Addition/O‐Trapping Rearrangement Sequence
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(2011)
摘要
An efficient, one-pot domino synthesis of new 2-amino-3-cyano-4H-chromene-4-carboxamide derivatives has been developed by the acid-induced conjugate addition of isocyanides to 2-imino-2H-chromene-3-carboxamides, followed by an intramolecular O-trapping rearrangement, with yields up to 92%. This newly established protocol was also used in multicomponent (3CR) mode.
更多查看译文
关键词
Isocyanides,Conjugate addition,Domino reactions,Rearrangement,Multicomponent reactions
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要