801: Cerclage with 17OH progesterone (17OHP)

To examine the differences in perinatal outcomes amongst patients with history of spontaneous preterm birth > 16 weeks receiving transvaginal cerclage or transvaginal cerclage plus intramuscular 17OHP. Retrospective, case-control study. Women with transvaginal cerclage placement identified over a 10-year period (7/2002- 5/2012) and a history of previous delivery between 16 and 36 weeks were included. Exclusion criteria were delivery at another institution, abdominal cerclage, multiple gestations, major fetal anomalies. Pregnancy data, intrapartum events, and neonatal outcomes were obtained from the medical record. Primary outcome was delivery at <24 weeks gestational age(wga). Variables assessed included maternal age, gestational age (GA) at cerclage, GA at delivery, preterm premature rupture of membranes, and birth weight. Statistical analysis was performed using Open Epi, version 2. Chi square and t-test were used for categorical and continuous variables, respectively. 411 patients were identified with a cerclage. Of the 260 who met inclusion criteria, 164 underwent transvaginal cerclage alone and 96 received cerclage + 17OHP. The 2 groups were not different with respect to maternal characteristics. Women with cerclage + 17OHP had a 60% reduction in delivery prior to viability, <24wga compared to cerclage alone (OR 0.41 [0.17-.91], p=.03). There was no difference in delivery <28wga or <37wga between the two group (OR .72[.38-1.3] and .99[.6-1.6], respectively). Neonatal weight was greater in the cerclage + 17OHP group than cerclage alone (2484± 1043 vs 2362±1255; p