Natural Withanolides: A Newly Defined Mechanism of Oxidation and Apoptosis as a Novel Effective Therapy for Triple Negative Breast Cancer In Vivo

Triple-negative breast cancer (TNBC) remains a therapeutic challenge despite multi-drug strategies with cytotoxics and targeted agents. As such, novel compounds with potent efficacy against TNBCs in vitro and in vivo represent an area of significant developmental interest. Natural withanolides derived from the North American Physalis plant exhibit potent anticancer effects against multiple tumor types. We hypothesize that these novel withanolides are a potent therapy for TNBC in vivo through a redefined mechanism of oxidation and apoptotic cell death.