The Isolation and Structure Elucidation of Zaragozic Acid C, a Novel Potent Squalene Synthase Inhibitor.

Claude Dufresne,Kenneth E. Wilson,Deborah L. Zink,John A. Smith,James D. Bergstrom,Marc M. Kurtz,Deborah J. Rew,Nallin Mary,Rosalind G. Jenkins,Ken Bartizal,Charlotte Trainor,Gerald F. Bills,Maria S. Meinz,Leeyuan Huang,Janet C. Onishi,James A. Milligan,Marina Mojena,Fernando Pelaez

ChemInform（1993）

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摘要

Abstract The novel zaragozic acid C ( 1 ) has been isolated as a potent inhibitor of squalene synthase. It was found to be a competitive inhibitor of rat liver squalene synthase with an apparent K i of 45 ± 15 pM, and a broad spectrum antifungal agent against both yeast and filamentous fungi.

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