Atopic donor status does not influence the uptake of the major grass pollen allergen, Phl p 5, by dendritic cells

Kazem Ashjaei,Dieter Palmberger,Merima Bublin,Erika Bajna,Heimo Breiteneder,Reingard Grabherr,Isabella Ellinger,Karin Hoffmannsommergruber

Journal of Immunological Methods（2015）

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摘要

Dendritic cells (DCs) are sentinels of the immune system for antigen recognition and uptake, as well as presentation to naïve T cells for stimulation or priming. Internalization and endocytic degradation of allergens by DCs are important steps required for T cell priming.

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关键词

APC,CLR,DAPI,DC,DC-SIGN,EE,EEA1,FCS,FITC,LAMP1,LE,MoDC,MR,NA,PBMC,PCC,Phl p 5,SF-nsLTP,SPT,Th cell,TLR

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