Abstract 19136: Incidence of Diabetes Mellitus in Patients with Congenital Heart Disease

Introduction: Today 0.8-1 % of all children are born with congenital heart defects (CHD) and most live into adulthood, with estimations and registry data indicating that 90-95% of all CHD now reach adulthood. CHD may increase the risk of infections and subsequently higher risk of diabetes type 1. Diabetes type 2 (T2D) increases and CHD could lead to a more sedentary lifestyle with a higher risk of developing T2D. Rhe relation between CHD and diabetes has previously not been investigated. Hypotheses: We estimated the risk of developing diabetes in a large cohort of patients with CHD as found in the nationwide diabetes registry in Sweden, NDR Methods: the National Diabetes Registry, NDR has an estimated coverage above 70% for Sweden. We identified patients with CHD in the NDR and compared to two controls groups, control group 1 never hospitalized paired patients with T1D or T2D and a second control group randomly selected paired patients with diabetes T1D or T2D and previous hospitalization for any reason. Both control groups were adjusted by age and gender. The analyzed characteristics were age, gender, type of diabetes, diabetes duration, systolic blood pressure, BMI, waist measurement, HbA1c, smoking, microalbuminuria, antihypertensive, lipid lowering drug use and type of hypoglycaemic treatment. Results: We found 1860 patients in the NDR with CHD as additional diagnosis. With a presumed prevalence of between 0.3 and 0.4% of the adult population, diabetes was found in 6.2 to 8.2% of all adults with CHD, for an odds-ratio of 1.35 (1.3-1.4, p<0.001) for diabetes of any kind to occur in patients with CHD as compared to adults without CHD. CHD and diabetes with the Swedish population at age 18-100 years CHD Total pop OR P Total no 25.000 (est) 7.562.648 With diabetes 1860 425.375 with diabetes 7.4% 5.6% 1.35 (1.3-1.4) <0.0001 Conclusion. Based on estimated prevalence of adults with congenital heart disease in Sweden, the prevalence of diabetes seems to be higher in the CHD population than in the population without CHD, given an OR of 1.35.