Abstract 12635: Obstructive Sleep Apnea Affects Non-Culprit Plaque Characteristics in Patients With Acute Myocardial Infarction: An Integrated Backscatter Intravascular Ultrasound Study

Background: Obstructive sleep apnea (OSA) is associated with a higher incidence of cardiovascular events. This study evaluated the effect of OSA on plaque composition of non-culprit lesions in patients with acute myocardial infarction (AMI). Methods: A non-culprit lesion was defined as at least three consecutive frames with a plaque burden of at least 40% on grayscale intravascular ultrasound (IVUS, Terumo, Tokyo, Japan). Grayscale IVUS and integrated backscatter intravascular ultrasound (IB-IVUS, YD, Nara, Japan) was performed in 73 non-culprit lesions in 54 patients who underwent primary percutaneous coronary intervention for AMI. Overnight sleep study was performed using Morpheus (Teijin, Tokyo, Japan) during the hospitalization. Based on apnea-hypopnea index (AHI), the patients were classified into the non or mild OSA group (AHI <15, 42 lesions, 30 patients) and the moderate or severe OSA group (AHI ≥15, 31 lesions, 24 patients). Results: Table shows grayscale IVUS and IB-IVUS measurements of the non-culprit lesions. The moderate or severe OSA group had a significantly greater percentage of lipid pool volume in non-culprit lesions than the non or mild OSA group, as well as a smaller percentage of fibrosis volume. Multiple linear regression analysis showed that moderate or severe OSA was independently associated with an increased percentage of lipid pool volume. Conclusion: Moderate or severe OSA is associated with a greater percentage of lipid pool volume and a smaller percentage of fibrosis volume in non-culprit lesions in patients with AMI. ![][1] [1]: /embed/graphic-1.gif