Abstract 9565: Impact of Hepatic GPAT1 or DGAT2 Deficiency on Plasma Lipids and MTP Inhibitor-Induced Elevation of Liver Triglycerides in Mice

Caroline Houde,Kenny K. Wong,Sheng-Ping Wang,David G. McLaren,Vivienne Mendoza,Ray Rosa,Paul L. Miller,Steven J. Stout,Shuo Quan,Aiwu Zhang, Andy Taggart,Thomas P. Roddy,Stephen F. Previs,Heather Zhou,Doug Johns,Brian K. Hubbard

Circulation（2011）

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摘要

Purpose: Systemic microsomal triglyceride transfer protein (MTP) inhibitors induce beneficial changes in the serum lipid profile in animals and humans, including reduced total and LDL cholesterol (...

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关键词

Cholesterol-lowering drugs,Lipids,Metabolism,Apolipoproteins,Biomarkers

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