Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation

Colloids and Surfaces A: Physicochemical and Engineering Aspects(2014)

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摘要
•Polyhydroxy surfactants are suitable surfactants for the stabilization of SLN.•Their use leads to small sized and physically stable SLN.•Their use enables the production of “skin-friendly” SLN for dermal drug delivery.•Physico-chemical properties of surfactants strongly influence size/stability of SLN.•Alkyl chain lengths of lipid matrix of SLN and stabilizer should be similar.
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关键词
Polyhydroxy surfactants,Solid lipid nanoparticles,SLN,Physical stability,Crystallinity, High pressure homogenization
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