First generation newkome-type dendrimer as solubility enhancer of antitumor benzimidazole carbamate

A first generation dendrimer was evaluated as solubility enhancer of the antitumor compound methyl (5-[propylthio]-1 H -benzimidazol-2-yl) carbamate. The dendrimer possess carboxylic acid as terminal groups, which provide high water solubility and a low cytotoxic character. The drug-dendrimer association significantly increases active compound solubility in water, avoiding aggregation. The formulation is stable several weeks in a wide temperature range. The formation of Langmuir monolayers in air–water interface of dendrimer-active compound blends evinces the viability of the complex to generate films for surface-mediated drug delivery systems.