Glycosylation-dependent activation of epithelial sodium channel by solnatide

Waheed Shabbir,Susan Tzotzos, Minela Bedak,Mohammad Aufy,Anita Willam, Martin Kraihammer, Alexander Holzner,Istvan Czikora,Parastoo Scherbaum-Hazemi,Hendrik Fischer,Helmut Pietschmann,Bernhard Fischer,Rudolf Lucas,Rosa Lemmens-Gruber

Biochemical Pharmacology（2015）

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摘要

(1) Solnatide activates ENaC pore-forming subunits. (2) Extracellular deglycosylation significantly reduces ENaC activation by solnatide. (3) Deglycosylation and carboxy terminal deletion diminishes solnatide induced ENaC activation.

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关键词

Epithelial sodium channel (ENaC),Glycosylation,Patch-clamp,Western blot

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