Tu1767 Detection of a LF82 Transcript in Fecal RNA Samples in Crohn's Disease Patients

G A A b st ra ct s to mesenteric lymph nodes and spleen. Increased TLR4 signaling resulted in significant down regulation of mucus protein Muc2 and epithelial barrier protein Zo-1. Although not significant, down regulation of polymeric immunoglobulin receptor (Pigr) and resistin-like molecule (Relmb) was observed in villin-TLR4 mice. Compared to WT mice, the villinTLR4 mice showed significant upregulation of antimicrobial peptides regenerating isletderived IIIγ (RegIIIg) possibly in response to increased mucosal-associated bacteria. Conclusion(s): Our results suggest that intestinal epithelial TLR4 signaling affects the abundance of the mucosa-associatedmicrobiota and regulates genes involved in host-microbial interactions. Dysregulation of TLR4 signaling may affect intestinal epithelial function and thus can influence the susceptibility to TLR4 dependent colitis-associated neoplasia.