Tu1880 Gastro-Oesophageal Reflux Disease -A Decade Later: Rising Prevalence in a Chinese Population

significant difference was observed for age (mean age 52 years in both groups, p=0.922), gender (50% men vs 34%, p=0.097) and body mass index (median 25 kg/m2 vs 24.7 kg/ m2, p=0.569).Patients with typical symptoms were non-responders in 86%, those with atypical symptoms alone in 74% and those with atypical symptoms dominant in 92%.The results of pH-impedance tests were not significantly different between PPI-responders and non-responders.The prevalence of PDS was significantly higher in PPI-non responders, while the prevalence of EPS and IBS almost reach statistical significance (Table ).Conclusion This study confirms that pH-impedance monitoring does not help to predict clinical response or non-response to PPI treatment.Functional digestive disorders (EBS, PDS or IBS) appear more frequent in PPI-non responders.Visceral hypersensitivity may be a predictive factor of PPI-non-response in patients with typical or atypical GERD symptoms.References 1.