Phosphorylation of MnSOD Protein at Serine-106 by Mitochondrial CyclinD1/CDK4 Enhances MnSOD Enzymatic Activity in Radiation-Induced Adaptive Response

Because of its accessibility the human skin is constantly exposed to solar ultraviolet (UV) radiation. It is increasingly appreciated that exposure of the mammalian skin to UV plays a causal and decisive role in acute and chronic skin damage including the development of skin cancer. UV exposure causes sunburn, pigmentation, hyperplasia, immunosuppression, DNA damage, photoaging and photocarcinogenesis. To cope with constant environmental damage the skin possesses elaborate enzymatic detoxification systems. This paper briefly focuses on the effect of solar radiation, particularly UV spectrum, on detoxification pathways in the skin. Specifically the effect of solar radiation on cytochrome P450, glutathione, superoxide dismutase, glutathione peroxidase, catalase, glutathione-S-transferase and ceruloplasmin has been discussed.